Monday, January 7, 2013

Fructose vs Glucose

Glucose: Increases insulin, increases GLP-1, decreases ghrelin: all of which increase satiety and decrease reward seeking behavior.

Fructose: Barely increases insulin, doesn't increase GLP-1, and doesn't decrease ghrelin, so after ingestion you will presumably still be hungry and looking for the next bag of skittles.

So, for a small study, rather interesting. Big difference in straight up fructose vs. glucose in how the brain and appetite centers react, and one would tend to think from the results that glucose decreases appetite and reduces food-seeking behaviors, whereas fructose doesn't really fill you up. Of course, no one drinks straight fructose unless you are glopping agave nectar into your tea, and it would have been interesting to see what the soda version of HFCS (from memory, I think it is 55% fructose, 42% glucose) did compared to straight-up glucose. And fizzy (hard to blind that one)! And cherry-flavored! Someone get me some healthy volunteers and an enormously expensive functional MRI machine!

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