Glucose: Increases insulin, increases GLP-1, decreases ghrelin: all of
which increase satiety and decrease reward seeking behavior.
Fructose: Barely increases insulin, doesn't increase GLP-1, and doesn't
decrease ghrelin, so after ingestion you will presumably still be hungry
and looking for the next bag of skittles.
So, for a small study, rather interesting. Big difference in straight up
fructose vs. glucose in how the brain and appetite centers react, and
one would tend to think from the results that glucose decreases appetite
and reduces food-seeking behaviors, whereas fructose doesn't really
fill you up. Of course, no one drinks straight fructose unless you are
glopping agave nectar into your tea, and it would have been interesting
to see what the soda version of HFCS (from memory, I think it is 55%
fructose, 42% glucose) did compared to straight-up glucose. And fizzy
(hard to blind that one)! And cherry-flavored! Someone get me some
healthy volunteers and an enormously expensive functional MRI machine!